Microplastics have become a major environmental concern in recent years, as they have been found to have detrimental effects on marine life, ecosystems, and human health. A new study published in Cell Discovery sheds light on how microplastics can impact hematopoietic stem cell renewal through interactions with gut microbiota and the hypoxanthine-Wnt axis.
Hematopoietic stem cells are responsible for producing all types of blood cells in the body, including red blood cells, white blood cells, and platelets. These cells play a crucial role in maintaining the body’s immune system and overall health. The study found that exposure to microplastics can disrupt the balance of hematopoietic stem cell renewal, leading to potential health issues.
One of the key mechanisms through which microplastics affect hematopoietic stem cell renewal is by altering the composition of gut microbiota. The gut microbiota plays a crucial role in regulating immune responses and maintaining overall health. When exposed to microplastics, the balance of gut microbiota can be disrupted, leading to inflammation and immune dysfunction. This, in turn, can impact the renewal of hematopoietic stem cells and compromise the body’s ability to produce healthy blood cells.
Furthermore, the study also found that microplastics can interfere with the hypoxanthine-Wnt axis, a signaling pathway that plays a critical role in regulating hematopoietic stem cell renewal. Hypoxanthine is a molecule that is essential for the production of DNA and RNA in cells, including hematopoietic stem cells. The Wnt signaling pathway is involved in regulating cell proliferation and differentiation. When exposed to microplastics, the levels of hypoxanthine can be altered, leading to dysregulation of the Wnt signaling pathway and impaired hematopoietic stem cell renewal.
Overall, this study highlights the complex ways in which microplastics can impact hematopoietic stem cell renewal through interactions with gut microbiota and the hypoxanthine-Wnt axis. It underscores the importance of further research into the effects of microplastics on human health and the environment, as well as the need for effective strategies to mitigate their impact. By understanding these mechanisms, we can work towards developing solutions to reduce the harmful effects of microplastics on our health and well-being.
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- Source Link: https://platohealth.ai/microplastics-dampen-the-self-renewal-of-hematopoietic-stem-cells-by-disrupting-the-gut-microbiota-hypoxanthine-wnt-axis-cell-discovery/